Zirconium Zr 89-desferrioxamine B monoclonal antibody huJ591

{
  "id": "MLC-T-ONC-017683",
  "term": "Zirconium Zr 89-desferrioxamine B monoclonal antibody huJ591",
  "field": "Oncology and biomedicine",
  "definition": "A radioimmunoconjugate comprised of the recombinant humanized monoclonal antibody J591 against prostate-specific membrane antigen (PSMA) conjugated to chelator desferrioxamine B (DFO-B) and labeled with the radioisotope zirconium Zr 89 with potential imaging property used in positron emission tomography (PET) imaging. Upon administration of zirconium Zr 89-desferrioxamine B monoclonal antibody huJ591, the antibody moiety binds to the extracellular domain of PSMA, and the radioisotope moiety may be detected using PET, thereby allowing the imaging and quantification of PSMA-expressing tumor cells. PSMA, or folate hydrolase is a cell surface peptidase highly expressed by malignant prostate epithelial cells and vascular endothelial cells of numerous solid tumor malignancies. In addition, upon PET imaging this agent provides high tumor:background tissue ratios.",
  "abbreviation": "89Zr-DFO-J591",
  "synonyms": [
    "zirconium Zr 89 desferrioxamine B monoclonal antibody huJ591",
    "89Zr-DFO-huJ591"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/zirconium-zr-89-desferrioxamine-b-monoclonal-antibody-huj591/"
}