zirconium Zr 89-ss-pertuzumab

{
  "id": "MLC-T-ONC-017702",
  "term": "zirconium Zr 89-ss-pertuzumab",
  "field": "Oncology and biomedicine",
  "definition": "A radioimmunoconjugate composed of pertuzumab, a humanized recombinant monoclonal antibody directed against the extracellular dimerization domain of the tyrosine kinase receptor human epidermal growth factor-2 (HER2; HER-2), and linked, using a site-specific bioconjugation method, to the radioisotope zirconium Zr 89 (Zr89), with potential use in the imaging of HER-2-expressing tumor cells upon positron emission tomography (PET). Upon administration of zirconium Zr 89-ss-pertuzumab, the pertuzumab moiety targets and binds to HER-2. After binding and internalization into HER-2-expressing tumor cells, Zr89 facilitates the visualization and detection of HER-2-expressing tumor cells using PET. This assesses HER2-expression and may predict or evaluate the tumor's response to certain HER-2-targeting chemotherapeutics. Site-specific bioconjugation may produce better defined and more homogeneous radioimmunoconjugates.",
  "synonyms": [
    "89Zr-ss-pertuzumab",
    "site-specifically-labeled 89Zr-pertuzumab",
    "Zr 89-ss-pertuzumab"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/zirconium-zr-89-ss-pertuzumab/"
}