Interlocking cap and vial

{
  "publication_number": "US11136617B2",
  "country": "US",
  "kind": "B2",
  "title": "Interlocking cap and vial",
  "abstract": "A cap that is securable to a vial includes a plug configured for insertion into an open end of the vial. An upper portion of the cap defines a probe recess with an open top end and configured to receive a distal end of a probe of a pipettor inserted into the open top end, to frictionally secure the cap to an end of the probe. The cap includes a radially-oriented annular surface with one or more locking members depending from a periphery of the annular surface. The locking members are spaced from the plug and each locking member includes a radial locking groove and a radial locking ridge beneath the radial locking groove. A lip of the vial snaps into the radial locking groove above the radial locking ridge to secure the cap to the vial when the plug is inserted into the open end of the vial.",
  "claims": [
    "1. A cap securable to a vial having an open end, the cap comprising: a lower portion including a plug configured to be inserted into the open end of the vial; an upper portion having a probe recess with an open end, wherein the probe recess is configured to receive a probe of a pipettor inserted into the open end to removably secure the cap to the probe; a radially-oriented annular surface; and one or more locking members extending longitudinally from the outer periphery of the annular surface in a direction away from the upper portion and disposed radially outwardly from the plug of the lower portion of the cap, wherein the one or more locking members define a radial locking groove and a radial locking ridge disposed distally from the radial locking groove, wherein the radial locking groove is configured to receive a lip of the vial to secure the cap to the vial when the plug of the lower portion is inserted into the open end of the vial, and wherein the lower portion, the upper portion, the annular surface, and the one or more locking members are formed by a unitary plastic piece.",
    "2. The cap of claim 1, wherein the probe recess has a closed bottom.",
    "3. The cap of claim 1, wherein the plug has a hollow portion formed therein, the hollow portion defining an inner surface within the plug.",
    "4. The cap of claim 1, wherein the plug has a closed distal end.",
    "5. The cap of claim 4, wherein the closed distal end has a convex surface.",
    "6. The cap of claim 5, wherein the closed distal end further includes a peripheral chamfer.",
    "7. The cap of claim 1, wherein the one or more locking members comprise two or more locking fingers disposed about a circumference of the annular surface.",
    "8. The cap of claim 1, wherein the radial locking groove and the radial locking ridge are oriented to face radially inwardly.",
    "9. The cap of claim 1, further comprising a flange extending radially outwardly and separating the lower portion from the upper portion, wherein the annular surface comprises a surface of the flange.",
    "10. The cap of claim 1, wherein the plug includes one or more ribs circumscribing the plug for contacting an inner surface of the vial when the plug is inserted into the open end of the vial.",
    "11. The cap of claim 1, wherein the cap is configured so that the annular surface of the cap contacts the lip of the vial when the cap is secured to the vial.",
    "12. An assembly comprising a vial and a separate cap in secured engagement with the vial, wherein the vial comprises a well with an open end and a radial lip; and wherein the cap comprises: a lower portion including a plug inserted into the open end of the vial and configured to provide a sealing engagement between an outer surface of the plug and an inner surface of the well; an upper portion having a probe recess with an open end, wherein the probe recess is configured to receive a probe of a pipettor inserted through the open end to removably secure the cap to the probe; a radially-extending annular surface; one or more locking members extending longitudinally from the outer periphery of the annular surface in a direction away from the upper portion and disposed radially outwardly from the plug of the lower portion of the cap, wherein the one or more locking members define a radial locking groove and a radial locking ridge disposed distally from the radial locking groove, wherein the radial lip of the vial is disposed within the radial locking groove to secure the cap to the vial when the plug of the lower portion is inserted into the open end of the vial, and wherein the lower portion, the upper portion, the annular surface, and the one or more locking members of the cap are formed by a unitary plastic piece.",
    "13. The assembly of claim 12, wherein the probe recess has a closed bottom.",
    "14. The assembly of claim 12, wherein the plug of the cap has a hollow portion formed therein, the hollow portion defining an inner surface within the plug.",
    "15. The assembly of claim 12, wherein the plug has a closed distal end.",
    "16. The assembly of claim 15, wherein the closed distal end has a convex surface.",
    "17. The assembly of claim 16, wherein the closed distal end further includes a peripheral chamfer.",
    "18. The assembly of claim 12, wherein the one or more locking members comprise two or more locking fingers disposed about a circumference of the annular surface.",
    "19. The assembly of claim 12, wherein the radial locking groove and the radial locking ridge of the cap are oriented to face radially inwardly.",
    "20. The assembly of claim 12, wherein the cap further comprises a flange extending radially outwardly and separating the lower portion from the upper portion, and wherein the annular surface comprises a surface of the flange.",
    "21. The assembly of claim 12, wherein the assembly contains a biological sample.",
    "22. The assembly of claim 21, wherein the biological sample is contained in an eluate.",
    "23. The assembly of claim 21, wherein the assembly further contains a PCR master mix comprising a Taq DNA polymerase, deoxynucleoside triphosphates, and magnesium chloride.",
    "24. The assembly of claim 21, wherein the assembly further contains an oil.",
    "25. A cap securable to a vial having an open end, the cap comprising: a lower portion including a plug configured to be inserted into the open end of the vial, wherein the plug has a closed distal end with a convex surface; an upper portion having a probe recess with an open end, wherein the probe recess is configured to receive a probe of a pipettor inserted into the open end to removably secure the cap to the probe; and means for securing the cap to the vial when the plug of the lower portion is inserted into the open end of the vial, wherein the lower portion, the upper portion, and the means for securing the cap to the vial are formed by a unitary plastic piece.",
    "26. The cap of claim 25, wherein the probe recess has a closed bottom.",
    "27. The cap of claim 25, wherein the closed distal end includes a peripheral chamfer.",
    "28. A cap securable to a vial having an open end and comprising: a lower portion including a plug configured to be inserted into the open end of the vial, wherein the plug has a closed distal end with a convex surface; an upper portion having a probe recess with an open end, wherein the probe recess is configured to receive a probe of a pipettor inserted into the open end to removably secure the cap to the probe; and a radial protrusion configured to cooperatively engage a mating radial protrusion of the vial for securing the cap to the vial when the plug of the lower portion is inserted into the open end of the vial, wherein the lower portion, the upper portion, and the radial protrusion are formed by a unitary plastic piece.",
    "29. The cap of claim 28, wherein the probe recess has a closed bottom.",
    "30. The cap of claim 28, wherein the closed distal end includes a peripheral chamfer."
  ],
  "description_excerpt": "The present disclosure relates to an interlocking cap and vial, wherein the cap is configured to be removably secured on the distal end of a probe of an automated pipettor.\n\nNone of the references described or referred to herein are admitted to be prior art to the claimed invention.\n\nMolecular assays are nucleic acid-based tests that are used in clinical diagnosis, screening, monitoring, industrial and environmental testing, health science research, and other applications to detect the presence or amount of an analyte of interest in a sample, such as a microbe or virus, or to detect genetic abnormalities or mutations in an organism. Molecular assays enabling quantification may permit practitioners to better calculate the extent of infection or disease and to determine the state of a disease over time. Quantitative molecular assays are also useful for monitoring the effectiveness of a therapy. A variety of known molecular assays can be employed to detect various diagnostic indicators.\n\nMolecular assays generally include multiple steps leading to the detection or quantification of a target nucleic acid in a sample. Targeted nucleic acids often include a region that is specific to an identifiable “group” of organisms or viruses, where the group is defined by at least one shared sequence of nucleic acid that is common to all members of the group and is specific to the group in the particular sample being assayed. Examples of nucleic acid-based detection methods are disclosed by Kohne in U.S. Pat. No. 4,851,330 and Hogan et al. in U.S. Pat. No. 5,541,308.",
  "cpc": [
    "C12Q 1/6806",
    "B01L 2200/026",
    "B01L 2200/0689",
    "B01L 2300/046",
    "B01L 3/50825",
    "B01L 3/527",
    "B01L 3/565",
    "B01L 7/5255",
    "C12Q 1/686",
    "G01N 2035/0418",
    "G01N 2035/0436",
    "G01N 35/04"
  ],
  "ipc": [
    "B01L 3/00",
    "B01L 7/00",
    "C12Q 1/6806",
    "C12Q 1/686",
    "G01N 35/04",
    "C12Q 1/68"
  ],
  "assignees": [
    "Gen Probe Inc"
  ],
  "inventors": [
    "Byron J. Knight",
    "David A. BUSE",
    "Norbert D. Hagen",
    "David Opalsky",
    "Tyler MOORE",
    "Anita PRASAD",
    "Bruce Richardson"
  ],
  "filing_date": "2020-09-29",
  "publication_date": "2021-10-05",
  "grant_date": "2021-10-05",
  "priority_date": "2013-03-14",
  "application_number": "US-202017036307-A",
  "family_id": "50489438",
  "cited_by_count": 4,
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