Nanocomposites for enhanced cellular payload delivery

{
  "publication_number": "US2026102503A1",
  "country": "US",
  "kind": "A1",
  "title": "Nanocomposites for enhanced cellular payload delivery",
  "abstract": "Generally, the present disclosure is directed to compositions and methods of using the same. In some embodiments, a composition described herein comprises a nanoparticle, a plurality of nanofibers disposed on an exterior surface of the nanoparticle, and a payload disposed within an interior of the nanoparticle. The nanoparticle has an average size in three dimensions, and the plurality of nanofibers has an average length in a long dimension. In some cases, a ratio of the average size of the nanoparticle to the average length of the nanofibers is between 2 and 250.",
  "claims": [
    "1. A composition comprising: a nanoparticle; a plurality of nanofibers disposed on an exterior surface of the nanoparticle; and a payload disposed within an interior of the nanoparticle, wherein the nanoparticle has an average size in three dimensions; wherein the plurality of nanofibers has an average length in a long dimension; and wherein a ratio of the average size of the nanoparticle to the average length of the nanofibers is between 2 and 250. 2. The composition of claim 1, wherein the ratio of the average size of the nanoparticle to the average length of the nanofibers is between 5 and 100. 3. The composition of claim 3, wherein the ratio of the average size of the nanoparticle to the average length of the nanofibers is between 5 and 30. 4. The composition of claim 1, wherein the plurality of nanofibers has an average length in a long dimension; and wherein the ratio of the average surface area of the nanoparticle to the average length of the nanofibers, in units of (μm), is between 0.6 and 4,000. 5. The composition of claim 1, wherein the average size of the nanoparticle in three dimensions is between 0.1 μm and 5 μm. 6. The composition of claim 1, wherein the average length of the nanofibers in the long dimension is between 20 nm and 50 nm. 7. The composition of claim 1, wherein the average width of the nanofibers in one or two dimensions is less than 10 nm. 8. The composition of claim 1, wherein the nanofibers are present in the composition in an amount of 0.5 to 15 wt. %, based on the total weight of the composition. 9. The composition of claim 1, wherein the exterior surface of the nanoparticle has an opposite charge compared to a solvent-facing charge density of the plurality of nanofibers. 10. The composition of claim 1, wherein the exterior surface of the nanoparticle is negatively charged or has a negative zeta potential. 11. The composition of claim 1, wherein the nanofibers have a positive solvent-facing charge density or a positive zeta potential. 12. The composition of claim 1, wherein the nanoparticle is formed from a biocompatible and/or biodegradable material. 13. The composition of claim 1, wherein the nanoparticle comprises a lipid nanoparticle or a liposome. 14. The composition of claim 1, wherein the nanoparticle is formed from an inorganic material. 15. (canceled) 16. (canceled) 17. The composition of claim 1, wherein the nanoparticle is formed from an organic material. 18. (canceled) 19. (canceled) 20. (canceled) 21. The composition of claim 1, wherein the nanofibers comprise polypeptide nanofibers. 22. The composition of claim 21, wherein the polypeptide nanofibers comprise 15 to 40 residues per peptide chain. 23. The composition of claim 21, wherein the nanofibers comprise self-assembled polypeptide nanofibers. 24. The composition of claim 21, wherein the nanofibers comprise multidomain peptides (MDPs). 25. The composition of claim 21, wherein the nanofibers have a peptide sequence of K x (QW) 6 E y, where x is an integer ranging from 8 to 15 and y is an integer ranging from 1 to 5 (SEQ ID NO: 4). 26. The composition of claim 25, wherein the nanofibers have a peptide sequence of K 10 (QW) 6 E 3 (SEQ ID NO: 1). 27. The composition of claim 1, wherein the payload comprises an imaging agent, a therapeutic agent, a theranostic agent, or a combination of two or more of the foregoing. 28. The composition of claim 1, wherein the payload is physically entrapped within the interior of the nanoparticle. 29. The composition of claim 1, wherein the payload is operable to diffuse out of the interior of the nanoparticle when the composition is disposed in an aqueous or biological environment. 30. The composition of claim 1, wherein the payload is present in the composition in an amount of 1-80 wt. %, based on the total weight of the composition. 31. The composition of claim 1, wherein the payload comprises nucleic acids, proteins, peptides, chemotherapeutics, vaccine components, antibiotics, or a combination of two or more of the foregoing. 32 - 43. (canceled)"
  ],
  "cpc": [
    "A61K 47/62",
    "A61K 47/6937",
    "B82Y 30/00"
  ],
  "filing_date": "2023-10-04",
  "publication_date": "2026-04-16",
  "application_number": "US-202319115088-A"
}