Benzylisoquinolinic solutions and method of making the same

{
  "publication_number": "US3692910A",
  "country": "US",
  "kind": "A",
  "title": "Benzylisoquinolinic solutions and method of making the same",
  "abstract": "Benzylisoquinolinic solutions and particularly injectable solutions are produced by forming an intimate mixture of appropriate proportions of benzylisoquinolinic compounds, aliphatic alkanol amines which serve as solubilizing agent, a buffer selected from salts of organic acids with alkanol amines or N-methylglucamine, and the proportion of water required to obtain the final solution of the desired concentration of the benzylisoquinolinic compound.",
  "claims": [
    "2. The method of claim 1 wherein said member (c) is added in an amount whereby said aqueous solution is a pH of from 7.8-8.5.",
    "3. The method of claim 1 wherein said member (b) additionally contains an anti-oxidant.",
    "4. A composition comprising an aqueous solution of polyhydroxybenzylisoquinoline or an ester thereof produced by the process of claim 1.",
    "5. A composition according to claim 4 additionally containing an anti-oxidant.",
    "6. A compoisition according to claim 5 wherein said anti-oxidant is at least one member selected from the group consisting of butylhydroxyanisol, nordihydroguaiantico and propylgallate.",
    "7. A composition according to claim 4 wherein said member (c) is a salt with an organic acid selected from the group consisting of citric acid, tartaric acid, succinic acid and maleic acid.",
    "8. A composition according to claim 7 wherein said member (c) is N-methylglucamine citrate.",
    "9. A composition according to claim 4 wherein said aqueous solution has a pH of between 7.8 and 8.5.",
    "10. A composition according to claim 4 wherein said member (b) is present in an amount of 100-200 mg/ml.",
    "11. A composition according to claim 4 wherein said polyhydroxybenzylisoquinoline is a member selected from the group consisting of 1-(3,4 dioxybenzyl)-6,7 dioxyisoquinoline and 1-(3, 4 dibenzoyloxybenzyl)-6,7 dibenzoyloxyisoquinoline.",
    "12. A pharmaceutical injectible solution comprising a composition according to claim 4 in dosage unit form."
  ],
  "cpc": [
    "A61K 47/18",
    "A61K 31/485",
    "A61K 9/0019"
  ],
  "ipc": [
    "A61K 31/485",
    "A61K 47/18"
  ],
  "inventors": [
    "Umberto Laguzzi"
  ],
  "filing_date": "1968-09-05",
  "publication_date": "1972-09-19",
  "grant_date": "1972-09-19",
  "priority_date": "1967-09-07",
  "application_number": "US-3692910D-A",
  "family_id": "11165135",
  "cited_by_count": 5
}