Printed transdermal drug delivery device

{
  "publication_number": "US4915950A",
  "country": "US",
  "kind": "A",
  "title": "Printed transdermal drug delivery device",
  "abstract": "A method for making transdermal drug delivery devices is provided which includes: laminating an adsorbent source layer to a pressure-sensitive, pharmaceutically acceptable contact adhesive; depositing a drug in liquid form on one face of the source layer; laminating an anchor adhesive layer to the opposing face of the source layer; and applying a drug-impermeable backing layer to the anchor adhesive, which backing layer then defines the upper surface of the device. The invention also encompasses transdermal drug delivery devices having a source layer in contact with and contained between anchor and contact adhesive layers, with a backing layer adjacent the anchor adhesive defining the upper surface of the device.",
  "claims": [
    "1. A method for making a transdermal delivery device, comprising: (a) laminating an adsorbent source layer to a pressure-sensitive, pharmaceutically acceptable contact adhesive layer, the contact adhesive layer comprised of a material that is permeable to the drug and which defines a basal surface for adhesion to skin; (b) printing a drug in liquid form onto the adsorbent fabric layer; (c) laminating an anchor adhesive layer to the source layer; and (d) applying a backing layer to the anchor adhesive layer which defines the upper surface of the device and is substantially impermeable to the drug.",
    "2. The method of claim 1, further including (e) applying a release liner layer that covers the lower surface defined by the contact adhesive layer, the release liner adapted to be removed from the device prior to use to expose the lower surface of the contact adhesive layer.",
    "3. The method of claim 1, wherein the drug is nicotine.",
    "4. The method of claim 3, wherein the nicotine is in free base form.",
    "5. The method of claim 3, wherein the nicotine is in salt form.",
    "6. The method of claim 1, wherein the drug is nitroglycerin.",
    "7. The method of claim 1, wherein the drug is fentanyl.",
    "8. The method of claim 7, wherein the drug is fentanyl base.",
    "9. The method of claim 7, wherein the drug is a pharmaceutically acceptable salt of fentanyl.",
    "10. The method of claim 1, wherein said drug in liquid form is deposited on the source layer with a percutaneous absorption enhancer that increases the permeability of the skin to the drug.",
    "11. A method for making a transdermal delivery device comprising: (a) laminating an adsorbent fabric layer to a pressure-sensitive, pharmaceutically acceptable contact adhesive layer, the contact adhesive layer comprised of a material that is permeable to the drug and which defines a basal surface for adhesion to skin; (b) printing an enhancer onto the adsorbent fabric layer; (c) laminating an anchor adhesive layer to the fabric layer; and (d) applying a backing layer to the anchor adhesive layer which defines the upper surface of the device and is substantially impermeable to the drug, wherein prior to said laminating, the drug is incorporated into the anchor adhesive layer, the contact adhesive layer, or both.",
    "12. A method for making a fragrance-releasing device, comprising: (a) laminating an adsorbent fabric layer, adapted to initially retain a fragrance in liquid form, to a pressure-sensitive, pharmaceutically acceptable contact adhesive layer which defines a basal surface; (b) printing a fragrance in liquid form onto the adsorbent fabric layer, whereby the fragrance is incorporated and initially retained therein; (c) laminating an anchor adhesive layer to the fabric layer, the anchor adhesive layer comprised of a material that is substantially pormeable to the fragrance; and (d) applying a backing layer to the anchor adhesive layer which defines the upper surface of the device and is substantially permeable to the fragrance."
  ],
  "description_excerpt": "1. Technical Field\n\nThis invention relates generally to transdermal drug delivery devices, and more particularly relates to such devices in which the drug is \"printed\", or deposited, on a central source layer during device fabrication. The invention thus encompasses a method for making transdermal drug delivery devices using a printing step to incorporate the drug into a source layer, and to drug delivery devices made using the novel method.\n\n2. Background of the Invention\n\nA variety of devices have been proposed or used for administering drugs transdermally. These devices are generally in the form of a bandage or skin patch that includes a reservoir that contains the drug and a pressure-sensitive adhesive component by which the device is attached to the skin. Depending upon the inherent permeability of the skin to a particular drug, the device may also include means for coadministering a percutaneous absorption enhancer or an element, such as a membrane interposed between the reservoir and the skin, that regulates the rate at which the drug or the percutaneous absorption enhancer is administered to the\n\nThe commercially available techniques for manufacturing these devices involve conventional casting and laminating processes. Actual incorporation of the drug is typically effected by (1) admixture of the drug with a compatible solvent, (2) incorporation of the drug into the drug reservoir by immersion in the drug/solvent admixture, and (3) evaporation of the solvent. In practice, this method has proved to have several disadvantages.",
  "cpc": [
    "A61K 9/7084",
    "A61F 13/02",
    "A61F 2013/0296"
  ],
  "ipc": [
    "A61F 13/02",
    "A61K 9/70"
  ],
  "assignees": [
    "Cygnus Research Corp"
  ],
  "inventors": [
    "Jesus Miranda",
    "Gary W. Cleary"
  ],
  "filing_date": "1988-07-05",
  "publication_date": "1990-04-10",
  "grant_date": "1990-04-10",
  "priority_date": "1988-02-12",
  "application_number": "US-21507488-A",
  "family_id": "26852227",
  "cited_by_count": 227,
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}