Oral adhesive sheet and oral adhesive preparation

{
  "publication_number": "US6455030B2",
  "country": "US",
  "kind": "B2",
  "title": "Oral adhesive sheet and oral adhesive preparation",
  "abstract": "An oral adhesive preparation has a substrate and a pressure-sensitive adhesive layer provided on at least one surface of the substrate, in which the pressure-sensitive adhesive layer contains a medicine, and is substantially insoluble in water or absorbs substantially no water. Further, an oral adhesive sheet comprising a separator release-treated on one or both surfaces thereof and a plurality of sections for application to oral mucous membrane mounted on at least one surface of the separator in a specified 2 to 5 by 2 to 5 arrangement with a specified proportion of a minimum inner diameter, Dp, of an incircle passing a center of gravity, W, of a section to a shortest distance, Di, of an adjacent section is 1.5 to 6. The substrate is preferably cloth such as non-woven fabric. Sections containing a local anesthetic can be used in surface anesthesia in dentistry.",
  "claims": [
    "1. An oral adhesive preparation comprising a substrate and a pressure-sensitive adhesive layer provided on at least one surface of said substrate, wherein said pressure-sensitive adhesive layer contains a medicine, and is substantially insoluble in water or absorbs substantially no water, wherein said substrate comprises a non-woven fabric that has a basis weight of 20 to 150 g/m 2 as prescribed in JIS-L1085 and a thickness of 0.1 to 1.0 mm as prescribed in JIS-L1085 and wherein a combination of the pressure-sensitive adhesive layer that contains a medicine and the substrate has a bending resistance (45° cantilever method) of 15 to 60 mm as prescribed in JIS-L1085.",
    "2. The oral adhesive preparation as claimed in claim 1, wherein the non-woven fabric has a bending resistance (45° cantilever method) of 10 to 80 mm as prescribed in JIS-L1085.",
    "3. The oral adhesive preparation as claimed in claim 1, wherein the non-woven fabric comprises as a major component at least one polyolefin fiber or polyester fiber.",
    "4. The oral adhesive preparation as claimed in claim 1, wherein the non-woven fabric is spun lace non-woven fabric.",
    "5. The oral adhesive preparation as claimed in claim 1, wherein said pressure-sensitive adhesive layer that is substantially insoluble in water or absorbs substantially no water comprises at least one member selected from the group consisting of acrylic-based polymers, rubber-based adhesives, silicone-based adhesives, vinyl ether-based adhesives, and vinyl ester-based adhesives.",
    "6. The oral adhesive preparation as claimed in claim 5, wherein the adhesive comprising an acrylic-based polymer is a copolymer of (meth)acrylic acid alkyl ester and (meth)acrylic acid.",
    "7. The oral adhesive preparation as claimed in claim 6, wherein the copolymer of (meth)acrylic acid alkyl ester and (meth) acrylic acid comprises a copolymer of 65 to 99% by weight of (meth)acrylic alkyl ester and 1 to 35% by weight of (meth)acrylic acid.",
    "8. The oral adhesive preparation as claimed in claim 1, wherein the medicine is a local anesthesia.",
    "9. The oral adhesive preparation as claimed in claim 8, wherein the local anesthesia is at least one member selected from the group consisting of lidocaine, cocaine, procaine, chloroprocaine, tetracaine, benzocaine, mepivacaine, prilocaine, bupivacaine, dibucaine, propoxycaine, etidocaine, dichlonine, and pharmacologically acceptable salts thereof.",
    "10. The oral adhesive preparation as claimed in claim 1, wherein the medicine is a systemic medicine.",
    "11. The oral adhesive preparation as claimed in claim 10, wherein the systemic medicine is at least one member selected from the group consisting of corticosteroids, analgesic antiphlogistics, narcotic sedatives, tranquilizers, antihypertensives, hypotensive diuretics, antibiotics, systemic anesthesia, antibacterial agents, antifungal agents, vitamins, coronary vessel dilators, antihistamines, expectorants, sex hormones, antidepressants, brain circulation improvers, antiemetics, antineoplastics, antiulcers, and biomedicines."
  ],
  "cpc": [
    "A61K 9/006",
    "A61K 31/167",
    "A61K 47/30",
    "A61L 15/44",
    "A61L 15/58",
    "A61L 2300/402",
    "Y10T 442/131"
  ],
  "assignees": [
    "NITTO DENKO CORP"
  ],
  "filing_date": "2001-07-20",
  "publication_date": "2002-09-24",
  "grant_date": "2002-09-24",
  "priority_date": "1999-03-03",
  "application_number": "US-90962301-A",
  "family_id": "26397201",
  "citations": [
    "EP0156080A1",
    "US3972995A",
    "US5750134A",
    "US5827525A",
    "US6325993B1",
    "WO9106290A1"
  ]
}