Human tumor necrosis factor polypeptides

{
  "publication_number": "US5288852A",
  "country": "US",
  "kind": "A",
  "title": "Human tumor necrosis factor polypeptides",
  "abstract": "A novel cloned DNA encoding a human tumor necrosis factor (TNF), a vector having said DNA inserted thereinto, a host transformed with said vector and a novel human TNF polypeptide, and processes for producing them.",
  "claims": [
    "1. A polypeptide having human tumor necrosis factor activity and being selected from the group consisting of (a) the polypeptide having the amino acid sequence of the following formula, and (b) a polypeptide having an amino acid sequence resulting from the addition of one or two amino acid residues from the precursor portion of said polypeptide (a) to the N-terminus of the following formula: ##STR131##",
    "2. A human tumor necrosis factor polypeptide claimed in claim 1 having the following amino acid sequence: ##STR132##",
    "3. A human tumor necrosis factor precursor polypeptide having the following amino acid sequence: ##STR133## or the said polypeptide having a methionine residue at the N-terminus.",
    "4. A pharmaceutical composition which comprises an anti-tumor effective amount of a polypeptide as defined in claim 1 as an active ingredient and a vehicle or a stabilizer therefor."
  ],
  "cpc": [
    "C07K 14/525",
    "A61K 38/00",
    "C07K 2319/00",
    "C07K 2319/034",
    "C07K 2319/75",
    "C12N 15/70",
    "Y10S 930/144"
  ],
  "assignees": [
    "DAINIPPON PHARMACEUTICAL CO"
  ],
  "filing_date": "1993-07-01",
  "publication_date": "1994-02-22",
  "grant_date": "1994-02-22",
  "priority_date": "1984-03-06",
  "application_number": "US-8444593-A",
  "family_id": "27550127",
  "citations": [
    "EP0131789A2",
    "EP0158286A2",
    "EP0166996A1",
    "EP0168214A2",
    "EP0183198A1",
    "JPS6030688A",
    "US4495282A",
    "US4677063A",
    "US4677064A",
    "US4677197A",
    "US4879226A",
    "WO8602381A1",
    "WO8603751A2",
    "WO8604606A1"
  ]
}