Use of long-wavelength electromagnetic radiation and photoprotective tumor localizing agents for diagnosis

{
  "publication_number": "US6274729B1",
  "country": "US",
  "kind": "B1",
  "title": "Use of long-wavelength electromagnetic radiation and photoprotective tumor localizing agents for diagnosis",
  "abstract": "A process of pathology or target tissue identification comprising administering an imaging material to a pathology or target tissue bearing mammalian host and irradiating the mammalian host with electromagnetic radiation having a wavelength between about 600 and 1100 nm, and especially in the region of 700 nm and longer wavelengths, whereupon the imaging material, which has been preferentially taken up by the pathology or target tissue, emits light and permits precise identification of the location, size and/or shape of the pathology or target tissue.",
  "claims": [
    "1. A compound having the structure:"
  ],
  "description_excerpt": "This is a divisional of application Ser. No. 09/282,610 filed Apr. 1, 1999, now U.S. Pat. No. 6,183,727 which is a continuation of application Ser. No. 09/081,175 filed May 19, 1998 now abandoned.\n\nThis invention relates to a method of diagnosing mammalian pathology or target tissues and more particularly to a photoidentification method of diagnosing pathology or target tissue using an optical imaging material containing an imaging agent and at least one auxiliary chromophore. The imaging material preferentially localizes in pathology or target tissue, absorbs light and in some cases fluoresces or phosphoresces upon exposure to light. The primary purpose of the auxiliary chromophore is prevention of photodamage to healthy tissue by the agent.\n\nCertain classes of molecules, including, for example, synthetic porphyrin derivatives, naturally occurring porphyrins and their derivatives, chlorophylls and their derivatives, purpurins, phthalocyanines, other cyclic tetrapyrroles, and fullerenes can act as imaging, detection and diagnostic agents for pathologies or target tissues including tumors, atherosclerotic and arthritic tissue, and diseased blood vessels. Administration of these agents to a human or other organism results in preferential localization of the agent in any of a variety of pathologies with respect to surrounding tissue. Irradiation of the organism with light of a given wavelength or wavelengths results in absorption of light by the agent. In some cases, the agent then emits light by fluorescence or phosphorescence.",
  "cpc": [
    "A61K 49/0052",
    "A61K 41/0071",
    "A61K 49/0021",
    "A61K 49/0036",
    "C07D 487/22"
  ],
  "ipc": [
    "A61K 41/00",
    "A61K 49/00",
    "C07D 487/22"
  ],
  "assignees": [
    "Arizona's Public Universities"
  ],
  "inventors": [
    "John Devens Gust, Jr.",
    "Ana L. Moore",
    "Thomas A. Moore",
    "William H. Ralston"
  ],
  "filing_date": "2000-02-01",
  "publication_date": "2001-08-14",
  "grant_date": "2001-08-14",
  "priority_date": "1998-05-19",
  "application_number": "US-49583800-A",
  "family_id": "26765287",
  "cited_by_count": 3,
  "citations": [
    "US5534506A",
    "US5552134A",
    "US5286474A",
    "WO1994008631A1",
    "US5610175A",
    "US5637608A",
    "US5707608A",
    "WO1997046262A2"
  ]
}