Self-sealing compositions

{
  "publication_number": "US9463260B2",
  "country": "US",
  "kind": "B2",
  "title": "Self-sealing compositions",
  "abstract": "Medical devices having a wound closure device and a reinforcing material are reacted in situ to create a self-sealing implant.",
  "claims": [
    "1. A self-sealing implant comprising: at least one staple and a polymeric buttress, wherein upon interaction of the at least one staple and the buttress, a hydrogel is formed.",
    "2. The self-sealing implant according to claim 1, wherein at least one of the staple and the buttress further comprises a material selected from the group consisting of succinimidyl containing polymers and multifunctional primary amines.",
    "3. The self-sealing implant according to claim 1, wherein the self-sealing implant further comprises at least one reactive component selected from the group consisting of electrophilic functional groups and nucleophilic functional groups.",
    "4. A method comprising the steps of: positioning a polymeric buttress comprising a first reactive component on a tissue; firing at least one staple comprising a second, complementary reactive component from a stapler, the at least one staple contacting the buttress; and, initiating a chemical reaction.",
    "5. The method according to claim 4, wherein either the first or second complementary reactive components comprise a polymer drug.",
    "6. The method according to claim 4, wherein either the first or second complementary reactive components comprise a medicinal agent.",
    "7. A method comprising the steps of: positioning a polymeric buttress comprising a first reactive component on a tissue; firing at least one staple comprising a second, complementary reactive component from a stapler, the at least one staple contacting the buttress; and, forming a hydrogel."
  ],
  "description_excerpt": "The present disclosure relates to self-sealing implants, and more particularly to self-sealing implants comprising a first reactive component and a second reactive component.\n\nWound closure devices, such as staples and sutures are commonly used in surgeries, for example, to resect tissues, transect tissues, and to create connections between tissues and organs. More particularly, wound closure devices such as surgical staplers are provided in several iterations including linear, circular, curved, for various types of surgeries including vascular, bariatric, thoracic and gynecologic.\n\nFluid (e.g., air and blood) leaks have been reported for certain procedures. One solution includes the use of an additional reinforcement such as a buttress. Buttresses or pledgets may be applied to the staple line to provide reinforcement to the staple line and/or reinforcement to delicate tissue. In use, staples or sutures are currently fired or sewn through a buttress. However, a need exists for suture or staple compositions which complement reinforcing materials, thereby reducing leak potential.\n\nSelf-sealing implants of the present disclosure include at least one wound closure device and a reinforcing material, wherein the wound closure device comprises a first reactive component and the reinforcing material comprises a second, complementary reactive component. More specifically, the wound closure device may include staples, sutures, clips, tacks, screws, pins, anchors, fasteners, sheaths, shunts, tissue barriers, stents and grafts. The reinforcing material may include tapes, felts, scaffolds, patches, pledgets, mesh, and buttresses.",
  "cpc": [
    "A61L 17/14",
    "A61B 17/0644",
    "A61B 17/07292",
    "A61B 2017/00495",
    "A61B 2017/00884",
    "A61B 2017/00898",
    "A61B 2017/0648",
    "A61F 2/0063",
    "A61F 2013/00451",
    "A61L 31/14",
    "A61L 31/145"
  ],
  "ipc": [
    "A61F 2/02",
    "A61B 17/064",
    "A61B 17/072",
    "A61B 17/08",
    "A61L 17/14",
    "A61L 31/14"
  ],
  "assignees": [
    "Covidien LP"
  ],
  "inventors": [
    "Joshua Stopek"
  ],
  "filing_date": "2010-06-04",
  "publication_date": "2016-10-11",
  "grant_date": "2016-10-11",
  "priority_date": "2009-06-29",
  "application_number": "US-79377610-A",
  "family_id": "43381563",
  "cited_by_count": 1183,
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}