Implant having controlled generation rate of reactive oxygen species and method of controlling generation of reactive oxygen species using the same

{
  "publication_number": "US11738123B2",
  "country": "US",
  "kind": "B2",
  "title": "Implant having controlled generation rate of reactive oxygen species and method of controlling generation of reactive oxygen species using the same",
  "abstract": "Provided is an implant having a controlled generation rate of reactive oxygen species and a method of controlling generation of reactive oxygen species using the same. The implant having a controlled generation rate of reactive oxygen species according to the present invention includes a body formed of a metallic material and having a groove, a first filling metal filling one region of the groove, and a second filling metal filling the groove on the first filling metal, wherein the second filling metal has an ionization tendency different from that of the first filling metal.",
  "claims": [
    "1. An implant having a controlled generation rate of reactive oxygen species, the implant comprising: a body made of a metallic material and having a groove; a first filling metal filling a region inside the groove; and a second filling metal filling the groove on the first filling metal, wherein the second filling metal has an ionization tendency different from that of the first filling metal, and both the first filling metal and the second filling metal have ionization tendencies higher than that of the body.",
    "2. The implant of claim 1, wherein the second filling metal has a higher ionization tendency than that of the first filling metal.",
    "3. The implant of claim 1, wherein one of the first filling metal and the second filling metal is zinc (Zn) or a Zn alloy, and the other is magnesium (Mg) or a Mg alloy.",
    "4. The implant of claim 1, wherein one of the first filling metal and the second filling metal is iron (Fe) or a Fe alloy, and the other is Zn, a Zn alloy, Mg, or a Mg alloy.",
    "5. The implant of claim 1, wherein one of the first filling metal and the second filling metal is a pure metal, and the other is an alloy including the pure metal as a main metal.",
    "6. The implant of claim 1, wherein the first filling metal and the second filling metal are alloys including the same main metal and having different composition ratios.",
    "7. The implant of claim 1, wherein the body comprises one selected from titanium (Ti), a Ti alloy, stainless steel, and a cobalt-chromium (Co - Cr) alloy.",
    "8. The implant of claim 1, wherein the groove has a shape extending vertically downward from a top surface of the body with a predetermined depth.",
    "9. An implant having a controlled generation rate of reactive oxygen species, the implant comprising: a body made of a metallic material and having a groove; and a filling metal filling at least one region inside the groove, wherein the groove comprises an upper region having a cross-sectional area different from a cross-sectional area of a lower region, the filling metal fills at least one portion of the upper region having the different cross-sectional area, and the filling metal has a higher ionization tendency than that of the body.",
    "10. The implant of claim 9, wherein the cross-sectional area of the lower region is smaller than the cross-sectional area of the upper region.",
    "11. The implant of claim 10, wherein the groove comprises a portion in which a cross-section increases in a tapered shape from the lower region to the upper region.",
    "12. The implant of claim 9, wherein the filling metal is zinc (Zn), a Zn alloy, magnesium (Mg), or a Mg alloy.",
    "13. The implant of claim 9, wherein the body is formed of titanium (Ti), a Ti alloy, stainless steel, or a cobalt-chromium (Co - Cr) alloy.",
    "14. The implant of claim 9, wherein the groove has a shape extending vertically downward from a top surface of the body with a predetermined depth.",
    "15. A method of controlling a generation rate of reactive oxygen species using an implant comprising a first filling metal and a second filling metal both having higher ionization tendencies than that of a body, the method comprising: a first step of generating reactive oxygen species by ionization of the second filling metal caused by galvanic corrosion between the second filling metal and the body; and a second step of generating reactive oxygen species in a concentration different from a concentration of reactive oxygen species obtained in the first step by ionization of the first filling metal caused by galvanic corrosion between the first filling metal and the body after the first step, and the first filling metal and the second filling metal have different ionization tendencies.",
    "16. The method of claim 15, wherein the ionization tendency of the second filling metal is higher than that of the first filling metal, and the concentration of reactive oxygen species generated in the second step is lower than the concentration of reactive oxygen species generated in the first step.",
    "17. A method of controlling a generation rate of reactive oxygen species using an implant having a groove formed to have different cross-sectional areas and filled with a filling metal having a higher ionization tendency than that of a body, the method comprising: a first step of generating reactive oxygen species by ionization of the filling metal having a first cross-sectional area; and a second step of generating reactive oxygen species in a concentration different from a concentration of reactive oxygen species obtained in the first step by ionization of the filling metal having a second cross-sectional area different from the first cross-sectional area after the first step.",
    "18. The method of claim 17, wherein the concentration of reactive oxygen species generated in the second step is lower than the concentration of reactive oxygen species generated in the first step.",
    "19. A method of manufacturing an implant having a controlling generation rate of reactive oxygen species, the method comprising: preparing a body having a groove; filling one region inside the groove with a first filling metal; and filling another region on the first filling metal with a second filling metal, wherein the second filling metal has an ionization tendency different from an ionization tendency of the first filling metal.",
    "20. The method of claim 19, wherein the second filling metal has a higher ionization tendency than that of the first filling metal.",
    "21. The method of claim 19, wherein the fillings with the first and second filling metals are performed by directly inserting the first and second filling metals into the groove.",
    "22. The method of claim 19, wherein the fillings with the first and second filling metals comprise: injecting a molten fluid of the first filling metal into the groove and solidifying the molten fluid; and injecting a molten fluid of the second filling metal onto the first filling metal and solidifying the molten fluid.",
    "23. The method of claim 19, wherein the fillings with the first and second filling metals comprise: inserting a powder of the first filling powder to the groove and sintering the powder; and inserting a powder of the second filling metal onto the first filling metal and sintering the powder.",
    "24. The method of claim 19, wherein the fillings with the first and second filling metals comprise: sequentially inserting powders of the first filling metal and the second filling metal to the groove and sintering the powders.",
    "25. A method of manufacturing an implant having a controlled generation rate of reactive oxygen species, the method comprising: preparing a body having a groove; and filling at least one region of the groove with a filling metal, wherein the groove comprises an upper region having a larger cross-sectional area than a cross-sectional area of a lower region, and the filling of the groove with the filling metal comprises filling the groove with the filling metal up to a portion of the upper region.",
    "26. The method of claim 25, wherein the filling of the groove with the filling metal is performed by directly inserting the filling metal into the groove.",
    "27. The method of claim 25, wherein the filling of the groove with the filling metal comprises injecting a molten fluid of the filling metal into the groove and solidify the molten fluid.",
    "28. The method of claim 25, wherein the filling of the groove with the filling metal comprises injecting a powder of the filling metal to the groove and sintering the powder.",
    "29. An implant having a controlled generation rate of reactive oxygen species, the implant comprising: a body formed in a shape corresponding to an implant hole of a fixation plate having a plurality of implant holes formed at intervals through which fixing implants configured to fix a fracture part of a broken bone are inserted, and inserted into a position corresponding to the fracture site of the bone among the implant holes; and a first filling metal filling a recessed portion recessed from one surface of the body, wherein the first filling metal has an ionization tendency higher than an ionization tendency of a metal constituting the body.",
    "30. The implant of claim 29, wherein the body is made of one metallic material selected from titanium (Ti), a Ti alloy, stainless steel, and a cobalt-chromium (Co - Cr) alloy.",
    "31. The implant of claim 29, wherein the first filling metal is zinc (Zn), a Zn alloy, magnesium (Mg), or an Mg alloy.",
    "32. The implant of claim 29, wherein a second filling metal having a higher ionization tendency than that of the first filling metal fills the recessed portion on the first filling metal.",
    "33. The implant of claim 32, wherein the first filling metal is zinc (Zn) or a Zn alloy, and the second filling metal is magnesium (Mg) or a Mg alloy.",
    "34. The implant of claim 32, wherein the first filling metal is iron (Fe) or a Fe alloy, and the second filling metal is Zn, a Zn alloy, Mg, or a Mg alloy.",
    "35. The implant of claim 29, wherein the recessed portion comprises an upper region having a larger cross-sectional area than a cross-sectional area of a lower region, and the first filling metal fills at least one portion of the upper region having the larger cross-sectional area than that of the lower region.",
    "36. A fracture fixation device comprising: a fixation plate disposed on at least one portion of a broken bone and having a plurality of implant holes formed at intervals; a first fixing implant penetrating one of the plurality of implant holes of the fixation plate to be inserted into a first fracture part of the bone to fix the first fracture part; a second fixing implant penetrating another implant hole of the fixation plate to be inserted into a second fracture part of the bone to fix the second fracture part; and a functional implant engaged into another implant hole of the fixation plate at a position corresponding to a fracture site of the bone, generating reactive oxygen species, and supplying the reactive oxygen species to the fracture site.",
    "37. The fracture fixation device of claim 36, wherein the functional implant does not comprise a threaded portion extending downward from a head portion and inserted into at least one portion of the bone."
  ],
  "description_excerpt": "The present invention relates to an implant having a controlled generation rate of reactive oxygen species and a method of controlling generation of reactive oxygen species using the same, and more particularly, to an implant having a controlled generation rate of reactive oxygen species such that a generation rate of reactive oxygen species is high at an early stage and decreases over time and a method of controlling generation of reactive oxygen species with time using the same.\n\nExtensive research into various physiological mechanisms of reactive oxygen species (ROS) has revealed an effect of the reactive oxygen species on promoting angiogenesis. In addition, reactive oxygen species have immune function capable of preventing infection of injury by bacteria or virus. However, reactive oxygen species are chemically unstable, and thus generation of excessive reactive oxygen species may cause problems such as damage to normal cell membranes and cells.\n\nMeanwhile, during or after a dental implant procedure, sites of surgery may be infected by bacteria or the like due to environmental properties of oral cavity. Such infection may cause osteomyelitis, periodontal disease, gum inflammation, and the like. Thus, at an early stage of the procedure, infection at the surgery site can be prevented by introducing reactive oxygen species having antimicrobial defense properties into the treatment site.",
  "cpc": [
    "A61L 31/16",
    "A61B 17/80",
    "A61B 17/8605",
    "A61B 17/866",
    "A61B 2017/00526",
    "A61B 2017/00889",
    "A61B 2017/00893",
    "A61F 2/2846",
    "A61K 33/00",
    "A61K 9/0024",
    "A61L 31/022",
    "A61L 31/14",
    "C25D 11/00",
    "F16B 35/04"
  ],
  "ipc": [
    "A61B 17/00",
    "A61B 17/80",
    "A61B 17/86",
    "A61F 2/28",
    "A61K 33/00",
    "A61K 9/00",
    "A61L 31/02",
    "A61L 31/16",
    "C25D 11/00",
    "F16B 35/04"
  ],
  "assignees": [
    "Korea Institute of Science and Technology KIST",
    "Korea University Research and Business Foundation"
  ],
  "inventors": [
    "Myoung-Ryul OK",
    "Jimin PARK",
    "Yu Chan Kim",
    "Hyun Kwang Seok",
    "Hyung-Seop HAN",
    "Hojeong JEON",
    "Hyunseon SEO",
    "Jee-Wook LEE",
    "Jin Kyung Jeon",
    "Gayoung JUNG",
    "Jong Woong Park",
    "Ji Hun Park"
  ],
  "filing_date": "2020-06-03",
  "publication_date": "2023-08-29",
  "grant_date": "2023-08-29",
  "priority_date": "2019-06-05",
  "application_number": "US-202016891195-A",
  "family_id": "73650937",
  "cited_by_count": 0,
  "citations": [
    "US6168633B1",
    "US20040230225A1",
    "US20110015756A1",
    "US20090326638A1",
    "US8114148B2",
    "KR20110114993A",
    "KR20130034288A",
    "KR20180080173A",
    "KR101878853B1",
    "KR20200140111A"
  ]
}