Anaphase promoting complex

{
  "id": "MLC-T-AGR-000339",
  "term": "Anaphase promoting complex",
  "field": "Agriculture and food",
  "definition": "An E3 ubiquitin ligase primarily involved in regulation of the metaphase-to-anaphase transition during mitosis through ubiquitination of specific cell cycle proteins. Enzyme activity is tightly regulated through subunits and cofactors, which modulate activation, inhibition, and substrate specificity. The anaphase-promoting complex, or APC-C, is also involved in tissue differentiation in the placenta, crystalline lens, and skeletal muscle, and in regulation of postmitotic neuronal plasticity and excitability.",
  "synonyms": [
    "anaphase-promoting complex-cyclosome",
    "anaphase-promoting complex/cyclosome"
  ],
  "subject": "Fields of Study",
  "see_also": [
    "ubiquitin-protein ligase"
  ],
  "references": [
    "Medical Subject Headings 2014",
    "NAL Agricultural Thesaurus and Glossary"
  ],
  "translations": {
    "es": "complejo promotor de la anafase"
  },
  "url": "https://mlchart.com/terminology/agriculture/anaphase-promoting-complex/"
}