Angiotensin-converting enzyme 2

{
  "id": "MLC-T-ENV-001439",
  "term": "Angiotensin-converting enzyme 2",
  "field": "Environment",
  "term_source": "Angiotensin-Converting Enzyme 2",
  "definition": "1. Transmembrane glycoprotein with an extracellular catalytic domain which functions as a carboxypeptidase. It cleaves a single C-terminal residue from a distinct range of substrates. The catalytic efficiency is 400-fold higher with angiotensin II as a substrate than with angiotensin I. Angiotensin-converting enzyme 2 is also is a functional receptor for the spike glycoprotein of the coronaviruses SARS-COV, SARS-COV2, and HCOV-NL63. [NLM Medical Subject Headings (MeSH)]]\n\n2. Angiotensin-converting enzyme 2 (805 aa, ~92 kDa) is encoded by the human ACE2 gene. This protein plays a role in both vasodilation and protein cleavage.",
  "subject": "Biological substances",
  "references": [
    "EPA EV-Biological Substances-Genes & Biological Molecules",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/environment/angiotensin-converting-enzyme-2/"
}