B-Cell Differentiation

{
  "id": "MLC-T-ENV-002908",
  "term": "B-Cell Differentiation",
  "field": "Environment",
  "definition": "In mammalian bone marrow, B-Cell Development consists of progressive differentiation from CD34+ progenitor cells to plasma and memory B cells by positive/negative selection in response to local signals, including antigens and cytokines. B cell development begins with immunoglobulin gene somatic recombination and pre-B cell receptor expression. Antigen-induced signal transduction via BCR-associated ITAM molecules activates B cell proliferation. Further differentiation involves additional immunoglobulin gene recombination and expression. Antigen-stimulated circulating (resting) B cells proliferate and differentiate into plasma and memory B cell clones expressing immunoglobulins with the same antigen recognition site.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/environment/b-cell-differentiation/"
}