Chromosome Translocation

{
  "id": "MLC-T-ENV-004982",
  "term": "Chromosome Translocation",
  "field": "Environment",
  "definition": "1. A chromosome alteration in which a whole chromosome or segment of a chromosome becomes attached to or interchanged with another whole chromosome or segment, the resulting hybrid segregating together at meiosis; balanced translocations (in which there is no net loss or gain of chromosome material) are usually not associated with phenotypic abnormalities, although gene disruptions at the breakpoints of the translocation can, in some cases, cause adverse effects, including some known genetic disorders; unbalanced translocations (in which there is loss or gain of chromosome material) nearly always yield an abnormal phenotype.\n\n2. Translocation is a type of chromosomal abnormality in which a chromosome breaks and a portion of it reattaches to a different chromosome. Chromosomal translocations can be detected by analyzing karyotypes of the affected cells.",
  "references": [
    "NIH Genetics Home Reference Glossary"
  ],
  "url": "https://mlchart.com/terminology/environment/chromosome-translocation/"
}