MLchartDataset catalogue

Drug metabolism

Term · Environment · MLC-T-ENV-008621

A series of chemical modifications of a drug compound by enzymatic activity that make the substrate (drug) more water soluble to allow its clearance from the body. Drug metabolism occurs in two phases: Phase I (biotransformation) involves oxidation, hydroxylation reduction, and hydrolysis. Phase II (conjugation) involves synthesis and conjugation.

Table 1. Record
IdentifierMLC-T-ENV-008621
FieldEnvironment
SubjectBiological substances
ReferencesNational Cancer Institute Thesaurus (CC BY 4.0)
Record as JSON
{
  "id": "MLC-T-ENV-008621",
  "term": "Drug metabolism",
  "field": "Environment",
  "term_source": "Drug Metabolism",
  "definition": "A series of chemical modifications of a drug compound by enzymatic activity that make the substrate (drug) more water soluble to allow its clearance from the body. Drug metabolism occurs in two phases: Phase I (biotransformation) involves oxidation, hydroxylation reduction, and hydrolysis. Phase II (conjugation) involves synthesis and conjugation.",
  "subject": "Biological substances",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/environment/drug-metabolism/"
}

Record 8,406 of 29,894 in Environment terminology (MLC-0121). Request the full dataset.