Drug metabolism
Term · Environment · MLC-T-ENV-008621
A series of chemical modifications of a drug compound by enzymatic activity that make the substrate (drug) more water soluble to allow its clearance from the body. Drug metabolism occurs in two phases: Phase I (biotransformation) involves oxidation, hydroxylation reduction, and hydrolysis. Phase II (conjugation) involves synthesis and conjugation.
| Identifier | MLC-T-ENV-008621 |
|---|---|
| Field | Environment |
| Subject | Biological substances |
| References | National Cancer Institute Thesaurus (CC BY 4.0) |
Record as JSON
{
"id": "MLC-T-ENV-008621",
"term": "Drug metabolism",
"field": "Environment",
"term_source": "Drug Metabolism",
"definition": "A series of chemical modifications of a drug compound by enzymatic activity that make the substrate (drug) more water soluble to allow its clearance from the body. Drug metabolism occurs in two phases: Phase I (biotransformation) involves oxidation, hydroxylation reduction, and hydrolysis. Phase II (conjugation) involves synthesis and conjugation.",
"subject": "Biological substances",
"references": [
"National Cancer Institute Thesaurus"
],
"url": "https://mlchart.com/terminology/environment/drug-metabolism/"
}
Record 8,406 of 29,894 in Environment terminology (MLC-0121). Request the full dataset.