Hypermethylation

{
  "id": "MLC-T-ENV-013734",
  "term": "Hypermethylation",
  "field": "Environment",
  "definition": "Hypermethylation appears to be a controlled, epigenetic, heritable, and aberrant DNA methylation reaction on gene promoter regions and CpG islands associated with loss of (e.g., tumor-suppressor) gene function in diverse cellular pathways through transcriptional silencing by the formation of transcriptionally repressive chromatin.",
  "subject": "Biological substances",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/environment/hypermethylation/"
}