Inducible Nitric Oxide Synthase

{
  "id": "MLC-T-ENV-014164",
  "term": "Inducible Nitric Oxide Synthase",
  "field": "Environment",
  "definition": "Induced by lipopolysaccharide, endotoxins, and cytokines and expressed as 2 alternative isoforms in liver, retina, bone cells, and airway epithelia by human NOS2A Gene (NOS Family), calcium/calmodulin stimulated homodimeric Nitric Oxide Synthase 2A binds FAD and FMN cofactors, contains a flavodoxin-like domain, requires BH4 which may stabilize the dimer, and synthesizes reactive free radical nitric oxide messenger (from L-arginine). NO has antimicrobial and antitumoral activities in macrophages. NOS2A binds SLC9A3R1. IL12 requires NOS2 to stimulate NK cell cytotoxicity and to activate STAT4 tyrosine-phosphorylation by TYK2 in innate immunity. Aspirin inhibits NOS2A. (NCI)",
  "abbreviation": "iNOS",
  "synonyms": [
    "NOS-2"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/environment/inducible-nitric-oxide-synthase/"
}