Ligand-independent chloride ion channel activation

{
  "id": "MLC-T-ENV-015729",
  "term": "Ligand-independent chloride ion channel activation",
  "field": "Environment",
  "term_source": "Ligand-Independent Chloride Ion Channel Activation",
  "definition": "A process that involves the detection of and alteration of either the voltage or pH across a membrane, and results in a chloride channel becoming permeable to Cl- and related ions, including HCO3-, I-, SCN- and NO3-. This interaction plays a crucial role in setting the potential of the resting membrane, but also functions to regulate pH, the transport of organic solutes and the migration, differentiation and proliferation of cells.",
  "subject": "Biological substances",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/environment/ligand-independent-chloride-ion-channel-activation/"
}