Mitotic Sister Chromatid Cohesion

{
  "id": "MLC-T-ENV-017538",
  "term": "Mitotic Sister Chromatid Cohesion",
  "field": "Environment",
  "definition": "The faithful segregation of genetic information requires highly orchestrated changes of chromosome structure during the mitotic cell cycle. The linkage between duplicated sister DNAs is established during S phase and maintained throughout G2 phase (cohesion). In early mitosis, dramatic structural changes occur to produce metaphase chromosomes, each consisting of a pair of compacted sister chromatids (condensation). At anaphase onset, a signal is produced to disrupt the linkage between sister chromatids (separation), allowing them to be pulled apart to opposite poles of the cell. (from PubMed 10966455)",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/environment/mitotic-sister-chromatid-cohesion/"
}