Peroxisome Proliferation

{
  "id": "MLC-T-ENV-020660",
  "term": "Peroxisome Proliferation",
  "field": "Environment",
  "definition": "Associated with hepatocellular carcinomas, Peroxisome Proliferation occurs in epigenetic \"non-genotoxic\" responses of hepatocytes to diverse peroxisome proliferator chemicals and involves, probably by a steroid superfamily receptor-based mechanism (PPARs), altered expression of cellular growth and/or differentiation genes, induction of peroxisomal enzymes, and possibly oxidative stress.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/environment/peroxisome-proliferation/"
}