Regulated intramembrane proteolysis

{
  "id": "MLC-T-ENV-023643",
  "term": "Regulated intramembrane proteolysis",
  "field": "Environment",
  "term_source": "Regulated Intramembrane Proteolysis",
  "definition": "A process that involves the proteolysis of an integral membrane protein at a site that is within its transmembrane domain. This cleavage causes the release of cytosolic fragments that can enter the nucleus and regulate transcription. [National Cancer Institute Thesaurus] DesignNote: Regulated intramembrane proteolysis of a transmembrane protein usually follows the proteolytic shedding of the extracellular domain. Regulated intramembrane proteolysis is involved in many biological processes including embryonic development, cholesterol signaling and Alzheimer disease.",
  "subject": "Biological substances",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/environment/regulated-intramembrane-proteolysis/"
}