Systemic Effects

{
  "id": "MLC-T-ENV-027574",
  "term": "Systemic Effects",
  "field": "Environment",
  "definition": "1. Toxic effects as a result of absorption and distribution of a toxicant to a site distant from its entry point.\n\n2. Effects observed at sites distant from the entry point of a chemical due to its absorption and distribution into the body.\n\n3. Systemic effects are those that require absorption and distribution of the toxicant to a site distant from its entry point, at which point effects are produced. Most chemicals that produce systemic toxicity do not cause a similar degree of toxicity in all organs, but usually demonstrate major toxicity to one or two organs. These are referred to as the target organs of toxicity for that chemical. Systemic effects do not include cancer.",
  "subject": "Health and safety",
  "references": [
    "Integrated Risk Information System (IRIS) Glossary; EPA 2003",
    "Drinking Water Technical & Legal Terms",
    "RAIS 2004"
  ],
  "url": "https://mlchart.com/terminology/environment/systemic-effects/"
}