Weight-of-Evidence for Carcinogenicity

{
  "id": "MLC-T-ENV-030266",
  "term": "Weight-of-Evidence for Carcinogenicity",
  "field": "Environment",
  "definition": "1. A system used by the U.S. EPA for characterizing the extent to which the available data support the hypothesis that an agent causes cancer in humans. Under EPA's 1986 risk assessment guidelines, the WOE was described by categories \"A through E\", Group A for known human carcinogens through Group E for agents with evidence of noncarcinogenicity. The approach outlined in EPA's guidelines for carcinogen risk assessment (2005) considers all scientific information in determining whether and under what conditions an agent may cause cancer in humans, and provides a narrative approach to characterize carcinogenicity rather than categories. Five standard weight-of-evidence descriptors are used as part of the narrative.\n\n2. A system used by the EPA for characterizing the extent to which available data support the hypothesis that an agent causes cancer in humans. The approach, outlined in EPA’s Guidelines for Carcinogen Risk Assessment (2005), considers all scientific information in determining the WOE. Five standard descriptors are used as part of the WOE narrative: (1) Carcinogenic to humans, (2) Likely to be carcinogenic to humans, (3) Suggestive evidence of carcinogenic potential, (4) Inadequate information to assess carcinogenic potential, and (5) Not likely to be carcinogenic to humans. Each of these descriptors is explained in its own glossary entry. You can read more details about each of these WOE narratives in the AirToxScreen Technical Support Document (https://www.epa.gov/AirToxScreen/airtoxscreen-technical-support-document).\n\n3. System used by the U.S. EPA for characterizing the extent to which the available data support the hypothesis that an agent causes cancer in humans. Under EPA's 1986 risk assessment guidelines, the WOE was described by categories \"A through E\", Group A for known human carcinogens through Group E for agents with evidence of noncarcinogenicity. The approach outlined in EPA's guidelines for carcinogen risk assessment (2005) considers all scientific information in determining whether and under what conditions an agent may cause cancer in humans, and provides a narrative approach to characterize carcinogenicity rather than categories. Five standard weight-of-evidence descriptors are used as part of the narrative.",
  "abbreviation": "WOE for Carcinogenicity",
  "synonyms": [
    "WOE-For-Carcinogenicity"
  ],
  "subject": "Air",
  "references": [
    "Integrated Risk Information System (IRIS) Glossary",
    "AirToxScreen Glossary of Terms"
  ],
  "url": "https://mlchart.com/terminology/environment/weight-of-evidence-for-carcinogenicity/"
}