2-methoxyestradiol

{
  "id": "MLC-T-ONC-000039",
  "term": "2-methoxyestradiol",
  "field": "Oncology and biomedicine",
  "definitions": [
    "2ME2. A drug that prevents the formation of new blood vessels that tumors need in order to grow. It is derived from estrogen and belongs to the family of drugs called angiogenesis inhibitors.",
    "An orally bioavailable estradiol metabolite with potential antineoplastic activity. 2-methoxyestradiol inhibits angiogenesis by reducing endothelial cell proliferation and inducing endothelial cell apoptosis. This agent also inhibits tumor cell growth by binding to tubulin, resulting in antimitotic activity, and by inducing caspase activation, resulting in cell cycle arrest in the G2 phase, DNA fragmentation, and apoptosis."
  ],
  "abbreviation": "2ME2",
  "synonyms": [
    "2-ME",
    "2-methoxy estradiol",
    "2-MeE2",
    "2-MeOE2"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/2-methoxyestradiol/"
}