3'-aminomethyl nicotine-P. aeruginosa r-exoprotein A conjugate vaccine

{
  "id": "MLC-T-ONC-009533",
  "term": "3'-aminomethyl nicotine-P. aeruginosa r-exoprotein A conjugate vaccine",
  "field": "Oncology and biomedicine",
  "definition": "A hapten-carrier immunoconjugate composed of the hapten trans-3'-aminomethyl nicotine conjugated to a recombinant P. aeruginosa exoprotein A, rendered nontoxic through amino acid depletion, with potential immunostimulating activity. Upon vaccination with 3'-aminomethyl nicotine-P. aeruginosa r-exoprotein A conjugate vaccine, the immune system may produce anti-nicotine antibodies. Antibody-bound nicotine cannot pass the blood brain barrier (BBB) to activate brain nicotine receptors. Nicotine, a small organic molecule that is not immunogenic, must be haptenized and conjugated to a carrier protein, such as nontoxic recombinant P. aeruginosa exoprotein A, to induce an antibody response. Aluminium hydroxide may be used as an adjuvant for this vaccine.",
  "synonyms": [
    "nicotine conjugate vaccine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/3-aminomethyl-nicotine-p-aeruginosa-r-exoprotein-a-conjugate-vaccine/"
}