5-fluorouracil/salicylic acid topical solution

{
  "id": "MLC-T-ONC-009553",
  "term": "5-fluorouracil/salicylic acid topical solution",
  "field": "Oncology and biomedicine",
  "definition": "A topical formulation containing 0.5 % of antimetabolite 5-fluorouracil (5-FU) and 10% of salicylic acid, with potential antimitotic and keratolytic activity. Upon cutaneous application, 5-FU in the 5-fluorouracil/salicylic acid topical solution impedes pyrimidine metabolism thereby inhibiting cell growth, while the salicylic acid induces anti-inflammatory response and results in keratolytic effect. This may result in the breakdown of keratinocytes and prevent proliferation of keratinocytes locally.",
  "synonyms": [
    "low-dose 5-fluorouracil/salicylic acid"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/5-fluorouracil-salicylic-acid-topical-solution/"
}