6 melanoma helper peptide vaccine

{
  "id": "MLC-T-ONC-009554",
  "term": "6 melanoma helper peptide vaccine",
  "field": "Oncology and biomedicine",
  "definition": "A multi-epitope vaccine containing the following six class II MHC-restricted peptides: gp100, MelanA/MART-1, two tyrosinase peptides, and the cancer/testis antigens MAGE-A3 and MAGE-A1,2,3,6, with potential antineoplastic activity. Upon administration, melanoma helper peptides induce an antigen-specific, Th1-dominant, CD4+ T-cell response, potentially augmenting cytotoxic T-cell (CTL) responses and maintaining immunologic memory against tumor cells expressing melanoma-specific antigens. The 6MHP vaccine may also induce a CD8+ T-cell response through epitope spreading, potentially priming subsequent immune responses against tumor cells.",
  "abbreviation": "6MHP",
  "synonyms": [
    "6MHP vaccine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/6-melanoma-helper-peptide-vaccine/"
}