adenosine A2A receptor antagonist PBF-509

{
  "id": "MLC-T-ONC-009664",
  "term": "adenosine A2A receptor antagonist PBF-509",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable adenosine A2A receptor (A2AR) antagonist, with potential antineoplastic activity. Upon administration, A2AR antagonist PBF-509 selectively binds to and inhibits A2AR expressed on T lymphocytes. This abrogates the adenosine/A2AR-mediated inhibition of T-lymphocytes and activates a T-cell-mediated immune response against tumor cells, thereby reducing proliferation of susceptible tumor cells. A2AR, a G protein-coupled receptor, is highly expressed on the cell surfaces of T-cells and, upon activation by adenosine, inhibits their proliferation and activation. Adenosine is often produced in excess by cancer cells.",
  "synonyms": [
    "A2AR antagonist PBF-509"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/adenosine-a2a-receptor-antagonist-pbf-509/"
}