Aglatimagene besadenovec

{
  "id": "MLC-T-ONC-009730",
  "term": "Aglatimagene besadenovec",
  "field": "Oncology and biomedicine",
  "definition": "An adenoviral vector engineered to express the herpes simplex virus thymidine kinase (HSV-tk) gene, which, when administered in conjunction with a synthetic acyclic guanosine analogue, possesses potential antineoplastic activity. Aglatimagene besadenovec is transduced into tumor cells, sensitizing tumor cells that overexpress HSV-tk to synthetic acyclic guanosine analogues. Subsequently, a low dose of a synthetic acyclic guanosine analogue such as valacyclovir (VCV) or ganciclovir (GCV) is given, which may preferentially kill tumor cells containing the adenoviral vector and overexpressing HSV-tk. Release of tumor-associated antigens (TAAs) by dying tumor cells may then stimulate an antitumor cytotoxic T lymphocyte (CTL) response.",
  "abbreviation": "ADV-tk",
  "synonyms": [
    "adenoviral vector encoding herpes simplex virus thymidine kinase",
    "virafir"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/aglatimagene-besadenovec/"
}