Allogeneic CRISPR-edited Anti-CD19 CAR T Cells PBLTT52CAR19

{
  "id": "MLC-T-ONC-009871",
  "term": "Allogeneic CRISPR-edited Anti-CD19 CAR T Cells PBLTT52CAR19",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of allogeneic T-lymphocytes transduced with a lentiviral vector encoding a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) CD19, with genetic modification of CD52 and T-cell receptor alpha constant (TRAC) loci via clustered regularly interspaced short palindromic repeats (CRISPR), with potential immunostimulating and antineoplastic activities. Upon administration, the allogeneic CRISPR-edited anti-CD19 CAR T cells PBLTT52CAR19 recognize and bind to CD19-overexpressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of CD19-positive tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. The editing of the CD52 gene may make the modified donor T-cells resistant to the anti-CD52 monoclonal antibody alemtuzumab, which is used during lymphodepletion. The editing of the TRAC may eliminate TCR expression, which may abrogate the potential induction of graft-versus-host disease (GvHD) by the donor T-cells, and may also result in uniform CAR expression and enhanced T-cell potency.",
  "synonyms": [
    "Allogeneic CRISPR-edited Anti-CD19 CAR T-cells PBLTT52CAR19",
    "Allogeneic CRISPR-edited Anti-CD19 CAR-T Cells PBLTT52CAR19"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/allogeneic-crispr-edited-anti-cd19-car-t-cells-pbltt52car19/"
}