allogeneic anti-CD19 CAR-T cells ALLO-501A

{
  "id": "MLC-T-ONC-009806",
  "term": "allogeneic anti-CD19 CAR-T cells ALLO-501A",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of allogeneic, frozen, 'off-the-shelf', universal transcription activator-like effector nuclease (TALEN)-engineered, gene-edited T-lymphocytes expressing a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19, with potential immunostimulating and antineoplastic activities. Using TALEN technology, the T-cell receptor (TCR) alpha chain and CD52 genes are deleted from the CAR19 T cells. Upon administration, allogeneic anti-CD19 CAR T cells ALLO-501A specifically target and bind to CD19-expressing tumor cells, thereby selectively lysing CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. Deletion of the CD52 gene makes the modified donor T cells resistant to the anti-CD52 monoclonal antibody alemtuzumab, which is used during lymphodepletion. The knockout of the TCR alpha gene eliminates TCR expression and is intended to abrogate the potential induction of graft-versus-host disease (GvHD) by the donor T cells. ALLO-501A lacks the rituximab recognition domains of ALLO-501.",
  "synonyms": [
    "allogeneic anti-CD19 CAR T lymphocytes ALLO-501A",
    "allogeneic CD19-specific CAR-T cells ALLO-501A"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/allogeneic-anti-cd19-car-t-cells-allo-501a/"
}