allogeneic anti-CD19 gamma-delta CAR-T cells UTAA09

{
  "id": "MLC-T-ONC-009807",
  "term": "allogeneic anti-CD19 gamma-delta CAR-T cells UTAA09",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of a subset of allogeneic T lymphocytes that express only gamma chain and delta chain T-cell receptors (TCRs) and that are transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19, with potential immunomodulating and antineoplastic activities. Upon administration, allogeneic anti-CD19 gamma-delta CAR-T cells UTAA09 specifically target and bind to tumor cells expressing CD19, thereby inducing selective toxicity in CD19-expressing tumor cells. Gamma delta T lymphocytes play a key role in the activation of the immune system and do not require major histocompatibility complex (MHC)-mediated antigen presentation to exert their cytotoxic effect. CD19 antigen is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies.",
  "synonyms": [
    "allogeneic anti-CD19 CAR gamma delta T cells UTAA09",
    "allogeneic anti-CD19 CAR gdT cells UTAA09"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/allogeneic-anti-cd19-gamma-delta-car-t-cells-utaa09/"
}