allogeneic gamma-delta T lymphocytes KB-GDT-01

{
  "id": "MLC-T-ONC-009885",
  "term": "allogeneic gamma-delta T lymphocytes KB-GDT-01",
  "field": "Oncology and biomedicine",
  "definition": "An off-the-shelf (OTS) preparation of unmodified, donor-derived T lymphocytes that express only gamma chain and delta chain T-cell receptors (TCRs), with potential immunomodulating and antineoplastic activities. Upon administration of the allogeneic gamma-delta T lymphocytes KB-GDT-01, these cells secrete interferon-gamma (IFN-g) and exert direct killing of tumor cells. In addition, these cells activate the immune system to exert a cytotoxic T-lymphocyte (CTL) response against tumor cells. Gamma-delta T lymphocytes play a key role in the activation of the immune system and do not require major histocompatibility complex (MHC)-mediated antigen presentation to exert their cytotoxic effect.",
  "synonyms": [
    "allogeneic gamma delta T cells KB-GDT-01",
    "allogeneic gamma-delta T cells KB-GDT-01",
    "Deltacel (TM)",
    "donor-derived gamma delta T-cells KB-GDT-01"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/allogeneic-gamma-delta-t-lymphocytes-kb-gdt-01/"
}