ex vivo-expanded allogeneic gamma 9 delta 2 T cells

{
  "id": "MLC-T-ONC-013480",
  "term": "ex vivo-expanded allogeneic gamma 9 delta 2 T cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of a subset of ex vivo-expanded, allogeneic T lymphocytes that express gamma 9 delta 2 T-cell receptors (TCRs), with potential immunomodulating and antineoplastic activities. Upon administration of the ex vivo-expanded allogeneic gamma 9 delta 2 T cells, these cells secrete interferon-gamma (IFN-g) and exert direct killing of tumor cells. In addition, these cells activate the immune system to exert a cytotoxic T-lymphocyte (CTL) response against tumor cells. Gamma delta T lymphocytes play a key role in the activation of the immune system and do not require major histocompatibility complex (MHC)-mediated antigen presentation to exert their cytotoxic effect. Gamma 9 delta 2 T cells, a subset of gamma delta T cells, may have a stronger association with antitumor immune responses compared with other gamma delta T-cell subtypes.",
  "synonyms": [
    "ex-vivo expanded allogeneic gamma9-delta2 T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/ex-vivo-expanded-allogeneic-gamma-9-delta-2-t-cells/"
}