Expanded/activated gamma/delta T lymphocytes

{
  "id": "MLC-T-ONC-013487",
  "term": "Expanded/activated gamma/delta T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of gamma delta T lymphocytes derived from donor T cells that have been expanded and activated ex-vivo and further depleted of alpha and beta T-cell receptors (TCRs), with potential immunomodulating and antineoplastic activities. Upon administration, these expanded/activated gamma delta (EAGD) T cells secrete interferon-gamma (IFN-g) and exert direct killing of tumor cells. In addition, these cells activate the immune system to exert a cytotoxic T-lymphocyte (CTL) response against tumor cells. Gamma delta T lymphocytes play a key role in the activation of the immune system and do not require major histocompatibility complex (MHC)-mediated antigen presentation to exert their cytotoxic effect.",
  "synonyms": [
    "expanded/activated gamma/delta T cells",
    "EAGD T cells",
    "EAGD T lymphocytes",
    "expanded and activated gamma delta T cells",
    "expanded and activated gamma/delta T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/expanded-activated-gamma-delta-t-lymphocytes/"
}