therapeutic ex vivo-expanded allogeneic gamma delta T cells

{
  "id": "MLC-T-ONC-017122",
  "term": "therapeutic ex vivo-expanded allogeneic gamma delta T cells",
  "field": "Oncology and biomedicine",
  "definition": "An off-the-shelf preparation of a subset of therapeutic, ex vivo-expanded, allogeneic T lymphocytes that express only gamma chain and delta chain T-cell receptors (TCRs), with potential immunomodulating and antineoplastic activities. Upon administration of the therapeutic ex vivo-expanded allogeneic gamma delta T cells, these cells secrete interferon-gamma (IFN-g) and exert direct killing of tumor cells. In addition, these cells activate the immune system to exert a cytotoxic T-lymphocyte (CTL) response against tumor cells. Gamma delta T lymphocytes play a key role in the activation of the immune system and do not require major histocompatibility complex (MHC)-mediated antigen presentation to exert their cytotoxic effect.",
  "synonyms": [
    "ex-vivo expanded allogeneic gd T lymphocytes",
    "therapeutic ex vivo-expanded allogeneic gamma, delta T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/therapeutic-ex-vivo-expanded-allogeneic-gamma-delta-t-cells/"
}