Allogeneic Variable Delta 1 Gamma-delta T-lymphocytes GDX012

{
  "id": "MLC-T-ONC-009955",
  "term": "Allogeneic Variable Delta 1 Gamma-delta T-lymphocytes GDX012",
  "field": "Oncology and biomedicine",
  "definition": "An off-the-shelf (OTS) preparation of allogeneic variable delta 1 (Vd1) gamma-delta (gd) T-lymphocytes, with potential immunomodulating and antineoplastic activities. Upon administration of the allogeneic Vd1 gd T-lymphocytes GDX012, these cells secrete interferon-gamma (IFN-g) and exert direct killing of tumor cells. In addition, these cells activate the immune system to exert a cytotoxic T-lymphocyte (CTL) response against tumor cells. Gamma delta T-lymphocytes play a key role in the activation of the immune system and do not require major histocompatibility complex (MHC)-mediated antigen presentation to exert their cytotoxic effect. Vd1 gd T-cells, a subset of gamma delta T-cells, recognize and are activated by cancer cells, and may therefore have a stronger association with antitumor immune responses compared with other gamma delta T-cell subtypes.",
  "synonyms": [
    "allogeneic Vd1 gd T cells GDX012",
    "allogeneic Vd1 gd T lymphocytes GDX012",
    "allogeneic gd T cells GDX012",
    "allogeneic variable delta 1 gamma-delta T cells GDX012",
    "gamma-delta T cells GDX012",
    "Allogeneic gd T-cells GDX012",
    "Allogeneic Variable Delta 1 Gamma-delta T-cells GDX012",
    "Allogeneic Vd1 gd T-cells GDX012",
    "Allogeneic Vd1 gd T-lymphocytes GDX012",
    "Gamma-delta T-cells GDX012"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/allogeneic-variable-delta-1-gamma-delta-t-lymphocytes-gdx012/"
}