autologous gamma delta T-cell receptor-expressing T cells TEG002

{
  "id": "MLC-T-ONC-011625",
  "term": "autologous gamma delta T-cell receptor-expressing T cells TEG002",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes genetically engineered to express a defined gamma delta T-cell receptor (TCR), with potential immunomodulating and antineoplastic activities. Upon administration of the autologous gamma delta TCR-expressing T cells TEG002, these cells secrete interferon-gamma (IFN-g) and exert direct killing of tumor cells. In addition, these cells activate the immune system to exert a cytotoxic T-lymphocyte (CTL) response against tumor cells. Gamma delta T lymphocytes play a key role in the activation of the immune system and do not require major histocompatibility complex (MHC)-mediated antigen presentation to exert their cytotoxic effect.",
  "synonyms": [
    "autologous gamma delta TCR-expressing T lymphocytes TEG002"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-gamma-delta-t-cell-receptor-expressing-t-cells-teg002/"
}