Autologous FRa-4SCAR-expressing T cells 4SCAR-FRa

{
  "id": "MLC-T-ONC-011624",
  "term": "Autologous FRa-4SCAR-expressing T cells 4SCAR-FRa",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of genetically modified autologous T cells transduced with a replication incompetent, self-inactivating lentiviral vector expressing a fourth generation chimeric antigen receptor (4SCAR) consisting of an anti-folate receptor alpha (FRa; folate receptor 1; FOLR1) single chain variable fragment (scFv) that is coupled to the costimulatory signaling domains CD28, CD137, CD27 and the zeta chain of the T-cell receptor (CD3zeta; CD3z), and is fused with the suicide gene inducible caspase 9 (iCasp9), with potential immunostimulating and antineoplastic activities. Upon administration, autologous FRa-4SCAR-expressing T cells 4SCAR-FRa are directed to and induce selective toxicity in FRa-expressing tumor cells. iCasp9 consists of a human FK506 drug-binding domain with an F36V mutation (FKBP12-F36V) linked to human caspase 9. If the administered T cells lead to unacceptable side effects, the chemical homodimerizer AP1903 can be administered. AP1903 binds to the drug binding FKBP12-F36V domain and induces activation of caspase 9, which results in the apoptosis of the administered T cells and enhances safety of this agent. FRa is overexpressed in various tumor cell types, and is associated with increased leukemic cell proliferation and aggressiveness. CD28, CD137 and CD27, T-cell surface-associated co-stimulatory molecules, are required for full T-cell activation and enhance both proliferation of T cells and antitumor activity.",
  "abbreviation": "4SCAR-FRa",
  "synonyms": [
    "FRa-specific 4th generation CART cells",
    "chimeric antigen receptor T cells 4SCAR-FRa",
    "autologous anti-FRa-CD28-CD137-CD27-CD3z-iCasp9 CAR T cells 4SCAR-FRa",
    "autologous 4S-FRa-CAR-T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-fra-4scar-expressing-t-cells-4scar-fra/"
}