autologous CD123-4SCAR-expressing T cells 4SCAR123

{
  "id": "MLC-T-ONC-011529",
  "term": "autologous CD123-4SCAR-expressing T cells 4SCAR123",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of genetically modified autologous T cells transduced with a replication incompetent, self-inactivating lentiviral vector expressing a fourth generation chimeric antigen receptor (4SCAR) consisting of an anti-CD123 (interleukin-3 receptor alpha chain or IL3RA) single chain variable fragment (scFv) that is coupled to the costimulatory signaling domains CD28, CD137, CD27 and the zeta chain of the T-cell receptor (TCR), and is fused with the suicide gene inducible caspase 9 (iCasp9), with potential immunostimulating and antineoplastic activities. Upon administration, autologous CD123-4SCAR-expressing T cells 4SCAR123 are directed to and induce selective toxicity in CD123-expressing tumor cells. iCasp9 consists of a human FK506 drug-binding domain with an F36V mutation (FKBP12-F36V) linked to human caspase 9. If the administered T cells lead to unacceptable side effects, the chemical homodimerizer AP1903 can be administered. AP1903 binds to the drug binding FKBP12-F36V domain and induces activation of caspase 9, which results in the apoptosis of the administered T cells and enhances safety of this agent. CD123 is normally expressed on committed blood progenitor cells in the bone marrow; its overexpression is associated with increased leukemic cell proliferation and aggressiveness. CD28, CD137 and CD27, T-cell surface-associated co-stimulatory molecules, are required for full T-cell activation and enhance both proliferation of T cells and antitumor activity.",
  "synonyms": [
    "anti-CD123 CAR-T cells 4SCAR123",
    "CD123-specific 4th generation chimeric antigen receptor-modified T cells",
    "CD123-4SCAR-expressing T lymphocytes",
    "4S-CD123-CAR-T cell",
    "4SCAR123 T cells",
    "anti-CD123-CD28-CD137-CD27-CD3z-iCasp9 CAR T cells 4SCAR123",
    "CD123-scFv/CD28/CD137/CD27/CD3z-iCasp9 T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-cd123-4scar-expressing-t-cells-4scar123/"
}