Therapeutic gamma delta T lymphocytes

{
  "id": "MLC-T-ONC-017124",
  "term": "Therapeutic gamma delta T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "A subset of therapeutic autologous T-lymphocytes that express a T-cell receptor (TCR) composed of one gamma chain and one delta chain, with potential immunomodulating and antineoplastic activities. Upon administration of the therapeutic gamma delta T-lymphocytes, these cells secrete interferon-gamma (IFN-g), and exert direct killing of tumor cells. In addition, these cells activate the immune system to exert a cytotoxic T-lymphocyte (CTL) response against tumor cells. Gamma delta T-lymphocytes play a key role in the activation of the immune system and do not require major histocompatibility complex (MHC)-mediated antigen presentation to exert their cytotoxic effect.",
  "synonyms": [
    "γδ T cells",
    "gd T cells",
    "gammadelta T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/therapeutic-gamma-delta-t-lymphocytes/"
}