allogeneic anti-CD19 CAR-gamma/delta T cells QH103

{
  "id": "MLC-T-ONC-009804",
  "term": "allogeneic anti-CD19 CAR-gamma/delta T cells QH103",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of a subset of allogeneic T lymphocytes that express only gamma chain and delta chain T-cell receptors (TCRs) and that are engineered to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19, with potential immunomodulating and antineoplastic activities. Upon administration, allogeneic anti-CD19 CAR-gamma/delta T cells QH103 target and bind to CD19-expressing tumor cells, thereby inducing selective toxicity in CD19-expressing tumor cells. Gamma/delta T lymphocytes play a key role in the activation of the immune system and do not require major histocompatibility complex (MHC)-mediated antigen presentation to exert their cytotoxic effect. CD19 is overexpressed on certain tumor cell types.",
  "synonyms": [
    "allogeneic anti-CD19 CAR gamma delta T cells QH103",
    "allogeneic anti-CD19 CAR gamma delta-T cells QH103",
    "allogeneic anti-CD19 CAR-gamma-delta T cells QH103",
    "allogeneic CD19 CAR-gamma delta T cells QH103",
    "allogeneic CD19 CAR-gdT cells QH103"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/allogeneic-anti-cd19-car-gamma-delta-t-cells-qh103/"
}