allogeneic anti-CD20/CD22 universal CAR-expressing T lymphocytes UCART20x22

{
  "id": "MLC-T-ONC-009815",
  "term": "allogeneic anti-CD20/CD22 universal CAR-expressing T lymphocytes UCART20x22",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of allogeneic, off-the-shelf (OTS), universal transcription activator-like effector nuclease (TALEN)-engineered T lymphocytes that have been genetically modified to express chimeric antigen receptors (CARs) specific for the tumor-associated antigens (TAAs) cluster of differentiation 20 (CD20) and CD22, with potential immunostimulating and antineoplastic activities. Using TALEN technology, the T-cell receptor (TCR) alpha chain (TRAC) and CD52 genes are inactivated. Upon administration, the allogeneic anti-CD20/CD22 universal CAR-expressing T lymphocytes UCART20x22 specifically recognize and induce selective toxicity in CD20- and CD22-expressing tumor cells. CD20 and CD22 are overexpressed in certain hematologic malignancies. Inactivation of the CD52 gene makes the CAR-T cells UCART20x22 resistant to anti-CD52 monoclonal antibody treatment that is used during preconditioning regimen to enhance the expansion and persistence of the CAR-T cells. The knockout of TRAC eliminates TCR expression and is intended to abrogate the potential induction of graft-versus-host disease (GvHD) by the CAR-T cells.",
  "synonyms": [
    "UCART20x22",
    "UCART 20x22",
    "UCART-20x22",
    "allogeneic anti-CD20/CD22 universal CAR-expressing T cells UCART20x22",
    "allogeneic anti-CD20/CD22 universal CAR T cells UCART20x22",
    "allogeneic anti-CD20/CD22 universal CAR-T cells UCART20x22",
    "CAR-T cells UCART20x22"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/allogeneic-anti-cd20-cd22-universal-car-expressing-t-lymphocytes-ucart20x22/"
}