allogeneic anti-CD20-CAR T cells PBCAR20A

{
  "id": "MLC-T-ONC-009814",
  "term": "allogeneic anti-CD20-CAR T cells PBCAR20A",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of allogeneic, off-the-shelf (OTS), T lymphocytes, derived from healthy donors, that have been genetically modified using a proprietary synthetic endonuclease-based system to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD20 (cluster of differentiation 20), with potential immunostimulating and antineoplastic activities. Upon administration, allogeneic anti-CD20-CAR T cells PBCAR20A specifically recognize and kill CD20-expressing tumor cells. The CD20 antigen, a non-glycosylated cell surface phosphoprotein, is a B-cell specific cell surface antigen expressed in B-cell lineage malignancies.",
  "synonyms": [
    "allogeneic anti-CD20 CAR T lymphocytes PBCAR20A"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/allogeneic-anti-cd20-car-t-cells-pbcar20a/"
}