Autologous anti-CD20 CAR transduced CD4/CD8 enriched T cells MB-CART20.1

{
  "id": "MLC-T-ONC-011392",
  "term": "Autologous anti-CD20 CAR transduced CD4/CD8 enriched T cells MB-CART20.1",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD20 (cluster of differentiation 20), and CD4/CD8 enriched, with potential immunostimulating and antineoplastic activities. Upon administration, MB-CART20.1 specifically recognize and kill CD20-expressing tumor cells. The CD20 antigen, a non-glycosylated cell surface phosphoprotein, is a B-cell specific cell surface antigen expressed in B-cell lineage malignancies and certain melanoma cell subpopulations.",
  "synonyms": [
    "MB-CART20.1",
    "autologous CD20-targeted CAR-transduced CD4/CD8-enriched T cells MB-CART20.1",
    "CD20-targeting CAR T cells MB-CART20.1",
    "anti-CD20 CAR T cells MB-CART20.1"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-cd20-car-transduced-cd4-cd8-enriched-t-cells-mb-cart20-1/"
}