autologous anti-CD1a CAR T cells OC-1

{
  "id": "MLC-T-ONC-011391",
  "term": "autologous anti-CD1a CAR T cells OC-1",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes that have been transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) specific for the T-cell surface glycoprotein CD1a, with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-CD1a CAR T cells OC-1 bind to and induce selective toxicity in CD1a-expressing tumor cells. CD1a, an antigen-presenting glycoprotein, is exclusively expressed in cortical T-cell acute lymphoblastic leukemia (T-ALL) and otherwise only normally expressed in developing cortical thymocytes and Langerhans cells.",
  "synonyms": [
    "autologous hCD1a-CAR T cells OC-1",
    "autologous anti-CD1a CAR-T cells OC-1"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-cd1a-car-t-cells-oc-1/"
}