CD44v6-specific CAR-T cells

{
  "id": "MLC-T-ONC-012410",
  "term": "CD44v6-specific CAR-T cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of genetically modified T lymphocytes transduced with a lentiviral vector encoding a fourth-generation specific chimeric antigen receptor (4SCAR) specific for CD44 variant domain 6 (CD44v6), with potential immunomodulating and antineoplastic activities. Upon administration, CD44v6-specific CAR T cells specifically recognize and kill CD44v6-expressing tumor cells. CD44, a transmembrane glycoprotein and hyaluronic acid receptor, is expressed in healthy tissue and overexpressed in numerous cancer cell types. CD44v6, the isoform containing the variant domain 6 of CD44 gene, plays a key role in tumor cell invasion, proliferation and metastasis.",
  "synonyms": [
    "4SCAR-CD44v6 T cells",
    "CD44v6-specific CAR gene-engineered T cells",
    "CD44v6 CAR-T cells",
    "anti-CD44v6 CAR T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/cd44v6-specific-car-t-cells/"
}