autologous anti-GPC2-CAR T cells

{
  "id": "MLC-T-ONC-011441",
  "term": "autologous anti-GPC2-CAR T cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for glypican-2 (GPC2), with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-GPC2-CAR T cells specifically target and bind to GPC2-expressing tumor cells, resulting in tumor cell lysis. GPC2, a heparan sulfate proteoglycan and a member of the glypican family, is overexpressed on certain tumor cell types while minimally expressed in normal, healthy cells.",
  "synonyms": [
    "anti-GPC2 CAR autologous T cells",
    "anti-GPC2-CAR autologous T lymphocytes",
    "autologous anti-GPC2 CAR-T cells",
    "autologous glypican-2-specific CAR T cells",
    "autologous GPC2 CAR T cells",
    "GPC2-targeted CAR autologous T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-gpc2-car-t-cells/"
}