anti-glypican 3-scFvGC33-CAR-expressing T lymphocytes

{
  "id": "MLC-T-ONC-010709",
  "term": "anti-glypican 3-scFvGC33-CAR-expressing T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) containing a single chain variable fragment (scFv) derived from the anti-glypican-3 (GPC3) monoclonal antibody GC33 (scFvGC33), with potential immunostimulating and antineoplastic activities. Upon administration, anti-GPC3-scFvGC33-CAR autologous T lymphocytes specifically target and bind to GPC3-expressing tumor cells, resulting in tumor cell lysis. GPC3, a heparan sulfate proteoglycan and a member of the glypican family, is overexpressed on certain tumor cell types while minimally expressed in normal, healthy cells.. GPC3 plays an important role in cellular proliferation and differentiation.",
  "synonyms": [
    "GPC3-CAR transduced autologous T cells",
    "glypican 3-specific chimeric antigen receptor expressed in autologous T cells",
    "autologous GAP T cells",
    "autologous GPC3-CAR T cells",
    "glypican 3-specific chimeric antigen receptor-expressing autologous T cells",
    "anti-GPC3-scFvGC33-CAR autologous T lymphocytes"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-glypican-3-scfvgc33-car-expressing-t-lymphocytes/"
}